A, Squamous cell carcinoma before radiation therapy. Granular erythroplakia of the floor of the mouth on the patient’s right side. B, Same lesion after initiation of radiation therapy. Note the large, irregular area of epithelial necrosis and ulceration of the anterior floor of the mouth on the patient’s right side. C, Normal oral mucosa after radiation therapy. Note resolution of the tumor and the radiation mucositis.