In many cases, there is no need for spider nevi to be treated. If they are not causing uncomfortable burning or itching and are not related to liver disease, then spider vessels are not harmful. If, however, they cause discomfort, or if you choose to have them treated for cosmetic purposes, you have several choices. Laser treatment Lasers aimed at the spider nevus can eventually cause it to fade and disappear. The laser and the heat it emits may cause some pain or discomfort, but this should go away as soon as the laser is removed. Two to five treatments are typically needed to completely fade the spider nevus.