Cluster Headache affect predominantly middle-aged men. Episode of severe unilateral periorbital pain occur daily for several weeks and are often accompanied by ipsilateral nasal congestion, rhinorrhea, lacrimation, redness of the eye and horner syndrome. Episodes typically occur at night awaken patient and last for between 15 minutes and 3 hours. Spontaneous remission then occurs and the patient remain well for weeks or months before another bout of closely spaced attack. Treatment with subcutaneous or internasal sumatritan or inhalation of 100% Oxygen may be triggered effective.