MEDizzy
MEDizzy
Vijay Kumar
Vijay Kumar10 months ago
Crescentic Glomerulonephritis

Crescentic Glomerulonephritis

Crescentic glomerulonephritis, also known as rapidly progressive glomerulonephritis, is characterized by the presence of extensive glomerular crescents (usually greater than 50%) as the principal histologic finding. The disease can be primary or secondary. Primary or idiopathic crescent glomerulonephritis is classified into the following types: Type 1 (anti-glomerular basement membrane [GBM] disease) presents with linear deposits of immunoglobulin G (IgG) Type 2 (immune-complex mediated) presents with granular deposits of immunoglobulin Type 3 (pauci-immune) presents with few or no immune deposits, antineutrophil cytoplasmic antibody-associated small-vessel vasculitis (SVV) that may be renal-limited or part of a systemic disease, for example, granulomatosis with polyangiitis (GPA). Type 4 includes combinations of types 1 and 3 Type 5 is ANCA-negative, pauci-immune renal vasculitis (5% to 10% of cases) A crescent is made up of proliferating epithelial cells that line the Bowman capsule and infiltrating macrophages. It is a marker of severe glomerular injury. The crescents may be circumferential or noncircumferential, and the presence of circumferential crescents in over 80% of glomeruli portends a poor prognosis.

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