The Cowper's glands, also known as bulbourethral glands, are a pair of small exocrine glands of the male reproductive system, located in the urogenital diaphragm, deeply located posterolateral to the membranous (or bulbous) portion of the urethra, and below the apex of the prostate. The glands empty their secretions into the penile urethra each via a small duct.The Cowper's glands (bulbourethral glands) are normal anatomic structures that are rarely present within a transrectal prostatic biopsy.Pathologic changes rarely arise, although Cowper's glands (bulbourethral glands) may mimic prostatic carcinoma.