Peripheral Palsy will affect the ipsilateral Orbicularis Oris m. as well as the mouth, resulting in inability to close the eyelid, while in Central 7 only the mouth muscles are affected. This happens because each CN7 gets tracts from both hemispheres for the eyelid muscles, so damage to one hemisphere still leaves eyelid functionality intact, whereas a peripheral damage, where all the tracts are combined and the final nerve is formed, will affect all function. Caution is needed if there are other indications of CNS damage, because a small percentage of humans have as an anatomic variation single-hemisphere CN7 formation. Not quite on topic, but an interesting note, if a patient has facial diplegia, meaning bilateral peripheral CN7 palsy, the possibility of Guillain-Barre must be investigated.

Peripheral facial palsy will affect all mimic muscles of half part of face,central facial palsy will affect only lower mimic muscles as upper mimic muscles have innervation from both hemispheres