Kyphosis treatment depends on the cause and severity of your condition. Medications Kyphosis treatment may include: Pain relievers. If over-the-counter medicines — such as acetaminophen (Tylenol, others), ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve) — aren't enough, stronger pain medications are available by prescription. Osteoporosis medications. Bone-strengthening medications may help prevent additional spinal fractures that would worsen your kyphosis.