Brugada syndrome is a heart rhythm disorder. Each beat of the heart is triggered by an electrical signal made by special cells in the right upper chamber of the heart. Tiny pores, called channels, on each of these cells direct this electrical activity, which makes the heart beat. In Brugada syndrome, a change in these channels causes the heart to beat too fast, creating a dangerous heart rhythm (ventricular fibrillation). As a result, the heart doesn't pump enough blood to the rest of the body. An irregular rhythm that lasts for a short time can cause fainting. Sudden cardiac death can occur if the irregular heartbeat doesn't stop. Brugada syndrome may be caused by: A structural problem in the heart, which may be hard to detect An imbalance in chemicals that help send electrical signals through the body (electrolytes) Use of certain prescription medications or cocaine