-#ductusarteruosis, what's it? -What's it has to do with #indomethacin & #dexamethasone? -an image for that plz?
The ductus arteriosus is a normal fetal artery connecting the main body artery (aorta) and the main lung artery (pulmonary artery). The ductus allows blood to detour away from the lungs before birth. Every baby is born with a ductus arteriosus. After birth, the opening is no longer needed and it usually narrows and closes within the first few days. Sometimes, the ductus doesn't close after birth. Failure of the ductus to close is common in premature infants but rare in full-term babies. In most children, the cause of PDA isn't known. Some children can have other heart defects along with the PDA.
first , Dexamethasone used before delivery, given to the mother gust basing on suspecting that this tube may not close ? , but i got the second part, that indomethacin is a vasconistrictor by action on dilatory PEGs it would close the tube given soon after delivery.
They could close it faster. Indomethacin (Indocin) Indomethacin is indicated for patent ductus arteriosus (PDA) closure, as it promotes closure of the PDA and generally has an onset of action within minutes. Thus, inhibition of prostaglandin synthesis by indomethacin results in constriction of the ductus arteriosus. Dexamethasone may reduce the incidence of PDA in premature infants who weigh less than 1000 g at birth and thereby reduce the incidence of BPD.