Hereditary Non-polyposis Colorectal Cancer

This video lecture talks about hereditary non-polyposis colorectal cancer (HNPCC), genetics involved behind it, cancers associated with it, its penetrance and expressivity, identification criteria, treatment protocol, surgical interventions available and finally what can be done for surveillance of next generation. Timeline: 0:00 – Topics to be covered 1:10 – Introduction 2:29 – Immunohistochemistry 3:09 – Genetics 5:25 – History of HNPCC 6:08 – Lynch syndrome: Introduction 7:05 – Associated cancers of Lynch syndrome 7:51 – Lynch syndrome cancer risk stratification 9:21 – Penetrance and expressivity 10:43 – Identification and criteria 12:24 – Treatment 12:49 – Grading algorithm 13:13 – Surgery in colon cancer and rectal cancer 15:58 – Follow-up 16:24 – Endometrial and ovarian cancer 16:58 – Adjuvant therapy, prognosis and prediction 18:39 – Next generation surveillance and chemoprevention 19:41 – Summary 20:18 – Discussion