This brief video goes over the topic of Peutz-Jeghers syndrome (PJS) which consists of hamartomatous polyps plus skin and mucosal macular melanin deposition. This video also covers the sub-topics of genetics involved, associated signs and symptoms, diagnostic modalities and treatment options relevant to PJS. Timeline: 0:00 – Introduction to Peutz-Jeghers Syndrome 1:27 – Important point to note 2:37 – Genetics 4:30 – Signs and symptoms 5:05 – Diagnosis 6:04 – Treatment