Watch this video to understand the molecular genetics and pathology associated with Huntington's disease, the affect it has on basal nuclei and its clinical manifestation due to that. Timeline: 0:00 - Introduction and learning objectives 0:31 - Huntington protein, its mutation and CAG repeats 4:15 - Pathogenesis of huntingtons disease 4:46 - Signs and symptoms 5:53 - Basal nuclei normal physiology 9:06 - Basal nuclei in Huntingtons and mechanism of disease