Deep fungal infections are found in places in your body other than your skin, like your lungs, blood, urinary tract or brain. Some are opportunistic infections, meaning that they usually only cause disease in people with weakened immune systems. Deep or invasive fungal infections include: Histoplasmosis. Histoplasma, the fungus that causes histoplasmosis, can infect your lungs, brain or other parts of your body. It’s commonly found in the Ohio and Mississippi River valleys. Coccidioidomycosis (Valley fever). Caused by the fungus Coccidioides, coccidioidomycosis can infect your lungs and, rarely, move to other parts of your body. It’s most common in California and Arizona. Blastomycosis. Blastomyces, the fungus that causes blastomycosis, commonly infects your bones, skin and lungs. Rarely, it can also infect your brain and spinal cord. Aspergillosis. Aspergillus, the mold that causes aspergillosis, can cause several types of lung infections, including allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis. It can also infect other parts of your body or form a fungus ball (aspergilloma). Candidal urinary tract infection. Bacteria cause most urinary tract infections (UTIs), but some are caused by yeast such as Candida. Invasive candidiasis. Various Candida species cause invasive candidiasis. It can infect your heart, blood (candidemia), brain, eyes (endophthalmitis), bones or other parts of your body. Pneumocystis pneumonia (PJP). The fungus Pneumocystis jirovecii can infect your lungs and cause Pneumocystis jirovecii pneumonia (PJP). Mucormycosis. A group of molds called mucormycetes cause mucormycosis. Mucormycetes can infect your sinuses and brain (rhinocerebral mucormycosis), lungs (pulmonary mucormycosis), intestines (gastrointestinal mucormycosis), skin (cutaneous mucormycosis) or many parts of your body at the same time (disseminated mucormycosis). Cryptococcosis. Cryptococcus neoformans and Cryptococcus gattii cause cryptococcosis. They usually infect your lungs, but sometimes can infect your brain and spinal cord (cryptococcal meningitis).