Symptoms Pulmonary edema symptoms may appear suddenly or develop over time. Symptoms depend on the type of pulmonary edema. Sudden (acute) pulmonary edema symptoms Difficulty breathing (dyspnea) or extreme shortness of breath that worsens with activity or when lying down A feeling of suffocating or drowning that worsens when lying down A cough that produces frothy sputum that may have blood in it A rapid, irregular heartbeat (palpitations) Anxiety, restlessness or a feeling that something bad is about to happen Cold, clammy skin Wheezing or gasping for breath Long-term (chronic) pulmonary edema signs and symptoms Awakening at night with a cough or breathless feeling that may be relieved by sitting up Difficulty breathing with activity or when lying flat Fatigue More shortness of breath than usual when you're physically active New or worsening cough Rapid weight gain Swelling in the legs and feet Wheezing