Statins and Breast Cancer
Statins May Protect From Breast Cancer Mortality Statin use after a breast cancer diagnosis was associated with a statistically significant decrease in the risk of dying from the disease. The protective effect was more pronounced in patients with estrogen receptor positive (ER+) disease, as well as in postmenopausal women and women with advanced tumors. Statins, the most widely prescribed cholesterol lowering medications, have been associated with improved and unchanged breast cancer outcomes in previous studies. Statin use was associated with a 26% lower risk of breast cancer–specific death after adjusting for comorbidities, demographics, concomitant medication use, and clinical factors. The association was attenuated in new users, defined as women for whom statins were not dispensed in the year before they were diagnosed (hazard ratio [HR], 0.91; 95% CI, 0.69 – 1.19). The protective effect was more pronounced in patients with ER+ disease (HR, 0.77), postmenopausal women (HR, 0.74), and women with stage IIIb, IIIc, or IV disease (HR, 0.65). The was no protective effect with respect to recurrence or distant metastases, and there was no effect in early-stage disease and for premenopausal women. Based on the strength of this preprint study that is currently undergoing peer review, investigators say further research is warranted to identify a subgroup of patients who might benefit from adjuvant statin therapy
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