Stages of a cold sore Stage 1: Tingling and itching occurs about 24 hours before blisters erupt. Stage 2: Fluid-filled blisters appear. Stage 3: The blisters burst, ooze, and form painful sores. Stage 4: The sores dry out and scab over causing itching and cracking. Stage 5: The scab falls off and the cold sore heals.