What are the treatments for leishmaniasis? Antiparasitic drugs, such as amphotericin B (Ambisome), treat this condition. Your doctor may recommend other treatments based on the type of leishmaniasis you have. Cutaneous leishmaniasis Cutaneous ulcers will often heal without treatment. However, treatment can speed healing, reduce scarring, and decrease risk of further disease. Any skin ulcers that cause disfigurement may require plastic surgery. Mucocutaneous leishmaniasis These lesions don’t heal naturally. They always require treatment. Liposomal amphotericin B and paromomycin can treat mucocutaneous leishmaniasis. Visceral leishmaniasis Visceral disease always requires treatment. Several medications are available. Commonly used medicines include sodium stibogluconate (Pentostam), amphotericin B, paromomycin, and miltefosine (Impavido