Symptoms Enlarged thyroid Enlarged thyroidOpen pop-up dialog box Common signs and symptoms of Graves' disease include: Anxiety and irritability A fine tremor of the hands or fingers Heat sensitivity and an increase in perspiration or warm, moist skin Weight loss, despite normal eating habits Enlargement of the thyroid gland (goiter) Change in menstrual cycles Erectile dysfunction or reduced libido Frequent bowel movements Bulging eyes (Graves' ophthalmopathy) Fatigue Thick, red skin usually on the shins or tops of the feet (Graves' dermopathy) Rapid or irregular heartbeat (palpitations) Sleep disturbance