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Sheeza Basharat
Sheeza Basharat2 months ago
Statins in Acute Pancreatitis⁠

Statins in Acute Pancreatitis⁠

Statins Linked to Lower Diabetes Risk After Acute Pancreatitis⁠ ⁠ Use of cholesterol-lowering statins was linked to a lower risk of developing a subtype of diabetes that occurs after acute pancreatitis, according to a new report.⁠ ⁠ The benefits of statins depended on the consistency of usage, with regular users having a lower risk of developing post-pancreatitis diabetes than irregular users. The results were similar with low, moderate, and high statin doses, as well as in cases of both mild and severe acute pancreatitis.⁠ ⁠ Patients with acute pancreatitis face at least a twofold increased risk of developing post-pancreatitis diabetes, the study authors write. ⁠ ⁠ In addition, the 5-year cumulative incidence of insulin-dependent post-pancreatitis diabetes was 2.4% among regular statin users and 6.6% among nonusers. Regular statin users had a 52% lower risk of developing insulin-dependent diabetes as compared with nonusers.⁠ ⁠ Daily dosage didn't demonstrate a linear dose-response relationship. That means high-dose statins may not be more effective in preventing diabetes as compared with lower doses, the study authors write.⁠ ⁠ Like all such studies, there is risk of bias and confounding in determining the actual risk. Nonetheless, the results provide a strong reason for confirmation in other datasets and for further study," the authors write in the latest edition of the journal, ⁠ Clinical Gastroenterology and Hepatology. ⁠ ⁠ By:

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