Statins in Acute Pancreatitis
Statins Linked to Lower Diabetes Risk After Acute Pancreatitis Use of cholesterol-lowering statins was linked to a lower risk of developing a subtype of diabetes that occurs after acute pancreatitis, according to a new report. The benefits of statins depended on the consistency of usage, with regular users having a lower risk of developing post-pancreatitis diabetes than irregular users. The results were similar with low, moderate, and high statin doses, as well as in cases of both mild and severe acute pancreatitis. Patients with acute pancreatitis face at least a twofold increased risk of developing post-pancreatitis diabetes, the study authors write. In addition, the 5-year cumulative incidence of insulin-dependent post-pancreatitis diabetes was 2.4% among regular statin users and 6.6% among nonusers. Regular statin users had a 52% lower risk of developing insulin-dependent diabetes as compared with nonusers. Daily dosage didn't demonstrate a linear dose-response relationship. That means high-dose statins may not be more effective in preventing diabetes as compared with lower doses, the study authors write. Like all such studies, there is risk of bias and confounding in determining the actual risk. Nonetheless, the results provide a strong reason for confirmation in other datasets and for further study," the authors write in the latest edition of the journal, Clinical Gastroenterology and Hepatology. By: https://www.instagram.com/p/CgH_qo3OsZ3/?igshid=YmMyMTA2M2Y=