Triple Whammy
A new study investigating a dangerous "triple whammy" in patients taking blood pressure medications, research into complications from cancer regimens, and recent findings about treatment and prevention concerns resulted in kidneys becoming this week's top trending clinical topic. The combination of three drugs — a diuretic; a renin-angiotensin system inhibitor, such as an angiotensin-converting ACE inhibitor or angiotensin receptor blocker; and an NSAID — increases the risk for kidney injury. New research has identified the mechanism responsible. Not all patients who take the "triple whammy" combination develop kidney problems. To better understand the mechanism responsible for injury, researchers used computational models to gauge interactions. Their simulations suggested that low water intake, the myogenic response, and drug sensitivity may predispose certain patients to develop triple whammy–induced acute kidney injury. Without these additional risk factors, the risk was not elevated when an ACE inhibitor and NSAID were combined. In contrast, when an ACE inhibitor, diuretic, and NSAID are combined, critical BP and eGFR regulatory mechanisms are simultaneously interrupted. By: https://www.instagram.com/p/CeDw3SBsTZQ/?utm_source=ig_web_copy_link