Blueberry Muffin Rash
Blueberry Muffin rash occurs because of extramedullary hematopoiesis in sites of different magnitudes and extensions. ⠀ ⠀ DIFFERENTIAL DIAGNOSIS: It includes the following: ⠀ ⠀ ✅Infectious etiologies, such as Toxoplasmosis, other (syphilis, varicella-zoster, parvovirus B19), rubella, cytomegalovirus, and herpes (TORCH) infections (especially congenital rubella)⠀ ⠀ ✅Blood dyscrasias (ABO incompatibility, Rh incompatibility, minor group incompatibility, twin-to-twin transfusion syndrome) ⠀ ⠀ ✅Malignancies (congenital leukemia, Langerhans cell histiocytosis [LCH], neuroblastoma)⠀ ⠀ ✅Skin disorders (hemangiomatosis, blue rubber bleb nevus syndrome).⠀ ⠀ ✅Cytomegalovirus (CMV) is the most common congenital infection and can cause a petechial rash due to thrombocytopenia.⠀ ⠀ ⏩CAUSE: The exact cause of prolonged dermal erythropoiesis in blueberry muffin syndrome is unknown, but it is hypothesized that during normal embryologic development, extramedullary hematopoiesis occurs in a number of organs, including the dermis and this activity persists until the fifth month of gestation.⠀ ⠀ ✅HISTOLATHOLOGY shows foci of dermal erythropoiesis along with aggregates of nucleated and non-nucleated erythrocyte precursors.⠀ ⠀ ✅In most cases, the illness regresses without complications within 4–8 weeks. By: https://www.instagram.com/p/Caeyy6HhYPa/?utm_medium=copy_link