Sexually Transmitted Diseases (STDs) Symptoms Some STDs remain asymptomatic until late in the course. Each STD presents with characteristic set of signs and symptoms. However, there are some symptoms common for all STDs. • Small painful bumps and sores near vagina, penis, anus or mouth • Rash, redness or painful swelling near vagina and penis • Skin rash • Dysuria i.e. painful urination • Weight loss • Diarrhea • Night sweats • Fever with chills • Jaundice • Abnormal discharge from vagina or penis • Intermenstrual bleeding • Dyspareunia i.e. painful sex • Severe itching near vagina or penis