ARBs Ex- Losartan , Valsartan , Candesartan MOA : * Selective and competitive antagonist of AT1 receptors. ——> vasodilation, inhibit catecholamine release, decrease Na and water retention. Treat hypertension 👉🏼Substitute of ACEIs in patients who can not tolerate sever cough or angioedema.👈🏼 ⭐️Doesn’t affect Bradykinin level⭐️ Side effects others similar to ACEIs except cough.