Multiple myeloma is a gammopathy. It is the most common malignant lesion that arises primarily from the bone. It affects bone marrow and causes variety of features on radiographs. These are described as under: 1. punched out lytic lesions 2. diffuse osteopenia 3. solitary lesions 4. osteosclerosing myeloma Reference: https://radiopaedia.org/articles/multiple-myeloma-1 Image via: https://radiopaedia.org/articles/multiple-myeloma-1