Sister Mary Joseph Nodule is a palpable, often painful mass bulging out of umbilicus. It may indicate presence of malignancy in pelvis or abdomen, Most common malignancies associated with Sister Mary Joseph Nodule are gastric, pancreatic, and colon cancer. Ovarian cancer or uterine cancer may also give rise to Sister Mary Joseph nodule. Reference: https://en.wikipedia.org/wiki/Sister_Mary_Joseph_nodule Image via: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2016;volume=12;issue=1;spage=428;epage=430;aulast=Safini