Abdominal Pain in Irritable Bowel Syndrome (IBS) Irritable Bowel Syndrome (IBS) causes severe pain in lower abdomen mainly. The abdominal pain in IBS is typical chronic visceral pain which is not associated with any damage to the digestive organs. In this long-term condition, the brain-gut axis is altered which produces distorted signals and hence, chronic pain shoots in the lower abdomen. Therefore, individuals with IBS focus over stability of brain-gut axis. Usually, in stressful conditions they do not keep calm which affects the brain-gut axis and alters its functioning.