Gail Curtis

almost 4 years ago

Varying Genetic Makeup in Viral Genotypes of HPV Low-risk HPV (Type 6 and 11) • the genome exists in a circular episomal DNA • the DNA is separate from the nuclear of host cell • involved in benign lesions High-risk HPV (Type 16 and 18) • the genome is integrated in the DNA of host cell • E6 and E7 proteins inactivate tumor suppressor proteins p53 and Rb leading to uncontrolled proliferation of host cell • involved in malignant lesions