MEDizzy
MEDizzy
mcg_35
mcg_35almost 4 years ago

How does the genetic make-up vary among the viral genotypes of papillomavirus (HPV)?

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almost 4 years ago

Varying Genetic Makeup in Viral Genotypes of HPV Low-risk HPV (Type 6 and 11) • the genome exists in a circular episomal DNA • the DNA is separate from the nuclear of host cell • involved in benign lesions High-risk HPV (Type 16 and 18) • the genome is integrated in the DNA of host cell • E6 and E7 proteins inactivate tumor suppressor proteins p53 and Rb leading to uncontrolled proliferation of host cell • involved in malignant lesions

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