The possible complications of large goiter are - Dysphagia - Dyspnea - Tracheomalacia - Difficulty in breathing leading to asphyxiation - Jugular compression - Horner’s Syndrome - Jod-basedow Syndrome i.e. hyperthyroidism after excessive exposure to iodine - Damage to recurrent laryngeal nerve - Lymphoma - Pain - Intranodular necrosis - Hemorrhage