Benediction sign arises as a consequence of peripheral neuropathy in hands. It is characterized by flexion of ring and middle fingers whereas rest of the fingers remain extended when patient is commanded to make a fist. The benedict sign occurs due to injury of median nerve. Reference: https://www.physio-pedia.com/Benediction_Hand_(aka_Benediction_Sign_or_Preacher%27s_Hand) Image via: https://www.physio-pedia.com/Benediction_Hand_(aka_Benediction_Sign_or_Preacher%27s_Hand)