Neurofibromatosis type I is the most common type of neurocutaneous disease. The loss of function mutation of NF1 gene encoding neurofibromin is attributed to the development of neurofibromatosis. Reference: https://www.sciencedirect.com/science/article/abs/pii/S0190962220323070 Image via: https://www.sciencedirect.com/science/article/abs/pii/S0190962220323070