Rash in Epstein Barr Virus Infectious Mononucleosis Patients usually present with rash which is why it holds clinical value. Rashes appear in the early course of EBV infectious mononucleosis. The rash is non-pruritic, maculopapular and generalized. They are evanescent and faint so they resolve rapidly. In drug-induced pseudolymphoma, the rash is non-pruritic and stays for quite long instead of resolving within a few days.