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Virgil Elliottalmost 4 years ago

What is the process of malignant conversion of skin lesions in patients with human papillomavirus (HPV) infection?

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almost 4 years ago

Malignancy of HPV Skin Lesions: HPV 16 and 18 (E6 and E7) proteins inhibits interferon pathway which suppresses the expression of MHC Class I on the surface of APC. This in turn does not activate CD8+ CTL which triggers viral immune evasion causing HPV persistence. It ultimately results in cancer. It usually occurs in fourth and fifth decade of life.

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