Gangrene is death of body tissue due to a lack of blood flow or a serious bacterial infection. Gangrene commonly affects the arms and legs, including the toes and fingers, but it can also occur in the muscles and in organs inside the body, such as the gallbladder. Gangrene is usually curable in the early stages with intravenous antibiotic treatment and debridement. Without treatment, gangrene may lead to a fatal infection. Gas gangrene can progress quickly; the spread of infection to the bloodstream is associated with a significant death rate.