Hiba Saleem11 months ago

c-ANCA VS p-ANCA (Autoantibodies) | Autoimmune Diseases

Anti-neutrophilic cytoplasmic antibodies (ANCA) are IgG autoantibodies against the cytoplasm of the neutrophils and monocytes. Anti-neutrophilic cytoplasmic antibodies (ANCA) have several patterns; the most important two being the cytoplasmic ANCA (c-ANCA) and the perinuclear ANCA (p-ANCA). ANCA are associated with vasculitis, such as microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss), rapidly-progressive glomerulonephritis (RPGN), anti-glomerular basement membrane antibodies (ant-GBM or Goodpasture's syndrome), as well as inflammatory bowel disease-associated. vasculitis.