Rash in Rubella and Epstein Barr Virus Infectious Mononucleosis In rubella, the rash is pink in appearance. The onset is first noticed on face from where it spreads to trunk and limbs. It disappears in the same sequence. In Epstein Barr Virus infectious mononucleosis, patients usually present with rash which is why it holds clinical value. Rashes appear in the early course of EBV infectious mononucleosis. The rash is non-pruritic, maculopapular and generalized. They are evanescent and faint so they resolve rapidly.