Primary causes are still unknown Secondary headaches are caused by health issues like acute sinusitis, concussion, ear infection, hangover, the flu, high blood pressure, brain tumor or brain aneurysm, to name a few. Treatment: Abortive/symptomatic (eg, oxygen, triptans, ergot alkaloids, and anesthetics) Preventive/prophylactic (eg, calcium channel blockers, mood stabilizers, and anticonvulsants)