Haneea Yasirover 3 years ago

Hirschsprung Disease

Hirschsprung Disease is also called Congenital Megacolon. This disease affects the colon and blocks stool from passing in newborns and children. The symptoms may appear right after birth however in mild cases, the disease is detected in childhood. It results from failure of parasympathetic ganglia to develop in the colon and rectum due to failure of migration of neural crest cells Mutation is caused by RET gene on chronosome 10q11. This gene codes for cell membrane tyrosine kinase receptor Symptoms in newborns: - Swollen Belly - Vomitting - Constipation Symptoms in children: - Chronic constipation - Gas - Fatigue - Swollen belly