According to Frank Sterling mechanism, increase in venous return causes increase in end-diastolic volume i.e. ventricular filling and preload. Increased volumes exert pressure on cardiomyocytes. Continuous increase in venous return stretches the cardiomyocytes and hence the length of sarcomeres in cardiac muscles increases. Increase in sarcomere length causes greater ejection force, greater ejection fraction and greater stroke volume.

Vishidho

almost 4 years ago

Force of contraction of mucsle is proportional to Intital length of muscle fibre

Josh

almost 4 years ago

The mechanism of Frank’s starling law is the introduction of fluid to promote preload and increase diastolic ventricular stretch. which is aimed to increase right ventricular cardiac output and ejection fraction.