Ramsha Zaheerabout 2 years ago

Dermatitis Herpetiformis

Dermatitis herpetiformis is an uncommon disease manifested by pruritic papules, vesicles, and papulovesicles mainly on the elbows, knees, buttocks, posterior neck, and scalp. It is associated with HLA antigens -B8, -DR3, and DQ-2. The diagnosis is made by light microscopy. Circulating antibodies to tissue transglutaminase are present in 90% of cases. Patients have gluten-sensitive enteropathy, but for the great majority it is subclinical. However, ingestion of gluten is the cause of the disease, and strict long-term avoidance of dietary gluten has been shown to decrease the dose of dapsone required to control the disease and may even eliminate the need for treatment.