Edward karimover 4 years ago
Atropine at low doses cause bradycardia? what’s the mechanism behind
Top rated comment
over 4 years ago
At low doses, atropine first acts in the CNS and causes inhibition of the inhibitory parasympathetic pathways. I-e M1 receptors instead of the M2 receptors found on the heart. The same initial effect is observed when atropine is given I/M or subcutaneously because now the drug is delivered in lower concentrations to the blood. The mechanism is still debated though!
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