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Valsalva Retinopathy

Valsalva Retinopathy

A 25-year-old woman at 11 weeks of gestation presented with sudden, painless, central “dark” vision after an episode of forceful vomiting (“morning sickness,” or emesis gravidarum). Visual acuity was 20/80 in the left eye. Funduscopy revealed sedimented preretinal hemorrhage that was enclosed by a dome-shaped preretinal membrane, features consistent with Valsalva retinopathy (Panel A). Examination of the right eye was normal, as were the blood pressure, complete blood count, prothrombin time, activated partial-thromboplastin time, and fasting blood glucose level. Improvement was seen at 2 weeks (Panel B), 2 months (Panel C), and 5 months (Panel D) after presentation, and the hemorrhage finally resolved. Visual acuity in the left eye improved to 20/25. Typically self-limiting, Valsalva retinopathy is caused by retinal capillary rupture after abrupt rises in intraocular venous pressure, which may occur with violent coughing or vomiting. The dome-shaped area can represent the posterior hyaloid or internal limiting membrane, or both. These preretinal structures are closely apposed to the retinal surface in young adults, although hemorrhage can dissect tissue planes and fill the potential spaces. Pathological analysis of the preretinal membrane after surgery is necessary to unambiguously identify it as the posterior hyaloid or internal limiting membrane and to determine whether the hemorrhage is subhyaloid or beneath the internal limiting membrane. Subhyaloid and internal-limiting-membrane hemorrhages can also occur with hematologic dyscrasias and cancers, hypertension, the rupture of a retinal macroaneurysm, subarachnoid hemorrhage, and the shaken-baby syndrome. Treatment options are laser membranotomy, vitrectomy, or as in this patient, observation.

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Top rated comment
over 5 years ago

So do these hemorrhages resolve naturally in their own ?

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over 5 years ago

Depends on the extent of blood vessel rupture

over 5 years ago

So since it is pre retinal hemorhage, what is outcome about pregnancy. Continuation or abortion??

over 5 years ago

My question is, is there any association with hyper in pregnancy or diabetes?

over 5 years ago

Could caffeine cause Valsalva Retinopathy? Asking because this happened to me, I used to drink coffee, and it happened without any valsalva maneuver(vomiting, couhing), so I stopped drinking coffee, as it were the only cause that could explain this, but now I'm feeling really bad as coffee helped me a lot as medical student

over 1 year ago

Originally published in NEJM here https://www.nejm.org/doi/full/10.1056/nejmicm1304102 , I am the Ophthalmic Photographer that captured these images, the use of copyrighted without attribution is not generally acceptable. A 25-year-old woman at 11 weeks of gestation presented with sudden, painless, central “dark” vision after an episode of forceful vomiting. Funduscopy revealed sedimented preretinal hemorrhage that was enclosed by a dome-shaped preretinal membrane.

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