Symptoms Nipple changes Signs and symptoms of breast cancer may include: A breast lump or thickening that feels different from the surrounding tissue Change in the size, shape or appearance of a breast Changes to the skin over the breast, such as dimpling A newly inverted nipple Peeling, scaling, crusting or flaking of the pigmented area of skin surrounding the nipple (areola) or breast skin Redness or pitting of the skin over your breast, like the skin of an orange