Cutaneous T-Cell Lymphoma
A 57-year-old man presented with crusted lesions on his nose that had developed over a period of 2 months (Panel A). He had occasional bloody discharge, without pain, and did not have constitutional or other systemic symptoms. Multiple skin biopsies eventually confirmed cutaneous T-cell lymphoma. Computed tomography revealed no lymphadenopathy or metastases. No evidence of bone marrow involvement was found. The patient received a course of radiotherapy, with a good response (Panel B). Three months later, he presented with ataxia. Imaging revealed infiltration involving the pons and cerebellum, with new pleuropulmonary nodules. Lung-biopsy findings were consistent with recurrent low-grade T-cell lymphoma. The patient received chemotherapy and then underwent autologous stem-cell transplantation. At his last follow-up, 10 months after transplantation, he continued to have remission.
