The day after he was born, an infant boy was observed to have nonbilious vomiting, choking after feeding, and abdominal distention with no meconium. The infant had been born at a gestational age of 35 weeks after the spontaneous premature rupture of membranes and had weighed 2900 g at birth. Physical examination at the time of birth had revealed no birth defects, and breast-feeding had commenced 6 hours after birth, in small amounts. Radiography of the abdomen while the patient was in the upright position revealed a single “bubble,” representing a dilated stomach with a fluid level, suggestive of congenital pyloric atresia, with a paucity of air distal to the stomach. A single bubble indicates congenital pyloric atresia, as compared with a double bubble, which indicates duodenal atresia. Congenital pyloric atresia is a rare condition and can be associated with other anomalies, such as epidermolysis bullosa, multiple intestinal atresia, esophageal atresia, Down’s syndrome, and congenital heart disease. Laparotomy and gastrotomy revealed a prepyloric membrane (congenital pyloric atresia type 1), which was excised, and parenteral nutrition was given for 5 days. The postoperative period was uneventful, with a good outcome during 2 years of follow-up.