Bitot’s spot is eye disorder characterized by superficial foamy patches, composed of epithelial debris (dead surface cells) and secretions, that develop on the exposed bulbar conjunctiva (white of the eye) as a manifestaion of advanced vitamin A deficiency due to malnutrition, alcoholism, old age Celiac or Crohn's diseases... Treatment is vitamin A supplementation and β-Carotene.
Vitamin A deficiency can also result in Metaplasia... which as a result changes the cell type in the eyes