Saddle pulmonary embolism represents a large pulmonary clot and a risk for sudden hemodynamic collapse. It refers to a large embolism/clot that straddles the bifurcation of the pulmonary trunk, extending into the left and right pulmonary arteries. If large enough, it can completely obstruct both left and right pulmonary arteries resulting in a sudden hemodynamic collapse and subsequent right heart failure and, unless treatment is prompt, death. Unfortunately, the most common presenting symptoms of dyspnea followed by syncope are relatively non-specific. The embolus is well seen by a contrast CT angiography scan. The patient had a chronic condition and has 4 stents already. He was put in circulatory arrest 3 times during the procedure. In these cases, patients are emergently transported to the Interventional Radiology suite and treated with a catheter directed thrombolysis and thrombectomy. Retrograde pulmonary perfusion was used in this case and the patient was put on a cardiopulmonary bypass.