Gangrene denotes the death of tissue, which results from the gradual loss of blood supply to a part of the body.The tissue slowly dies because it receives little or no oxygen and nutrients from the blood, but it does not become infected (i.e. In cases of wet gangrene). It is the most common complication of chronic conditions such as diabetes, arteriolosclerosis, peripheral artery disease as well as Burger's disease and frostbite in this cases and often the very first symptoms experienced are numbness and tingling sensation in the affected area.Credit @doctor.zg