MEDizzy
MEDizzy
USMLE
Medicine test
A 65-year-old Caucasian female with a history of DM, HTN, and a large anterior wall MI 5 years ago presents to the clinic complaining of shortness of breath. At baseline the patient finds it difficult to do any household chores. She has shortness of breath at rest and is homebound because of her symptoms. Vital signs are: Temperature = 98.7°F, HR = 62, RR = 19, BP = 160/85 mm Hg, oxygen saturation = 90% on room air. There are bibasilar crackles with scattered expiratory wheezes. There is also 2+ pitting edema of the lower extremities. JVP is measured just above the clavicle. An ECG reveals left ventricular hypertrophy (LVH), with Q waves and T-wave inversions in V1 to V4 and diffuse nonspecific ST segment abnormalities. A CXR shows cardiomegaly and considerable congestion of the pulmonary vasculature. Prior echocardiogram obtained 1 year prior shows EF 30% with wall motion abnormalities. Labs are normal including CBC, Cr, K. The patient’s medications include losartan, carvedilol, and aspirin. What is the most important long-term intervention for this patient?
Explanation
ExplanationSpironolactone. The patient has stage IV systolic heart failure and spironolactone is shown to decrease mortality in these patients as it is cardioprotective. β-Blockers, ACE inhibitors, and ICDs are also shown to decrease mortality in patients with systolic heart failure. Isosorbide dinitrate and hydralazine are shown to decrease mortality in class III/IV heart failure in African Americans but this patient is Caucasian and not expected to receive that same benefit. Digoxin and furosemide do not decrease mortality in any heart failure patients.
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