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USMLE
Diseases of the Blood
All of the following statements regarding hereditary spherocytosis are true Except:
Explanation
ExplanationSplenectomy alone does not completely eliminate hemolysis in hereditary spherocytosis. This is because while the spleen is the major site of erythrocyte destruction in individuals with hereditary spherocytosis, some hemolysis may still occur in other organs, particularly the liver and bone marrow. After splenectomy, the liver and bone marrow take over some of the functions of the spleen, including the removal of abnormal red blood cells. While this reduces hemolysis, it does not completely eliminate it. Therefore, individuals who have undergone splenectomy for hereditary spherocytosis may still experience some degree of hemolysis, although it is typically less severe than before splenectomy.
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