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USMLE
Gastrointestinal Physiology
After secretion of trypsinogen into the duodenum, the enzyme is converted into its active form, trypsin, by which of the following?
Explanation
ExplanationLiberation of the enzyme enteropeptidase (enterokinase) from the duodenal mucosal cells causes the inactive trypsinogen to be converted to the active form, trypsin. Enteropeptidase contains 41% polysaccharide. It is this high level of polysaccharide that protects enteropeptidase from digestion. Trypsin is responsible for the conversion of chymotrypsinogens and other proenzymes into their active forms.
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